#Download anti spyware not just easyone trial#

#Download anti spyware not just easyone trial#

Analysis of the value of further information indicated that a randomized controlled trial on catheter securement devices is potentially worthwhile. To guide the optimal future trial design, the expected costs and benefits of the alternative trial designs were estimated and compared. Probabilistic Monte Carlo simulation was used to characterize uncertainty surrounding the study results and to calculate the expected value of additional information. An economic evaluation was performed using data from a multi-arm randomized controlled pilot study comparing the efficacy of four types of catheter securement devices: standard polyurethane, tissue adhesive, bordered polyurethane and sutureless securement device. To apply value of information methods to the results of a pilot study on catheter securement devices to determine the optimal design of a future larger clinical trial. However, in addition to sample size calculation, value of information analysis can optimize other aspects of research design such as possible comparator arms and alternative follow-up times, by considering trial designs that maximize the expected net benefit of research, which is the difference between the expected cost of the trial and the expected value of additional information.

Value of information analysis has been proposed as an alternative to the standard hypothesis testing approach, which is based on type I and type II errors, in determining sample sizes for randomized clinical trials.

Tuffaha, Haitham W Reynolds, Heather Gordon, Louisa G Rickard, Claire M Scuffham, Paul A Value of information analysis optimizing future trial design from a pilot study on catheter securement devices.